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ORIGINAL ARTICLE
Year : 2011  |  Volume : 7  |  Issue : 27  |  Page : 260-264

Cardiovascular effects of Teucrium polium L. extract in rabbit


1 Department of Physiology, Cardiovascular Research Center, Mashhad, Iran
2 Department of Biology, Sciences School, Azad University of Mashhad, Mashhad, Iran
3 Department of Internal Medicine and Medical School, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
4 Department of Clinical Microbiology and Virology in Ghaem Hospital and Buali Research Institute, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran

Correspondence Address:
Seed Niazmand
Department of Physiology, Cardiovascular Research Center and Medical School, Mashhad University of Medical Sciences (MUMS), Mashhad
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.84244

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Background: Teucrium polium L. (TP) have been used in herbal medicine for different purposes such as antispasmodic, antidiabetic and lowering blood lipid. In the present study, the impact of aqueous-ethanol extract of TP on blood pressure, heart rate and intraventricular pressure was investigated in rabbit. Materials and Methods: Twenty-four NWZ rabbits weighed (2-3 kg) were randomly divided into four groups. In each experiment, two groups of six rabbits received jugular injection of either TP extract (20, 40 and 80 mg/kg) or normal saline for blood pressure effects and two groups for intraventricular pressure. Then, blood pressure, heart rate and intraventricular pressure were measured via carotid cannula using pressure transducer connected to a power lab system, and the data were pooled from independent, single-blinded experiments for each group. Results: Treatment with 80 mg/kg of TP extract significantly depressed the mean arterial blood pressure (12.5%, P< 0.05). However, there was no significant decrease in the 20 or 40 mg/kg dose or normal saline treatment group. Moreover, the extract increased (dp/dt)max (P<0.05), maximum left ventricular pressure (LVPmax) (P<0.05) and decreased (dp/dt)min significantly (P<0.05), there was no meaningful effect on left ventricular end-diastolic pressure (LVEDP). Conclusion : The present results demonstrated the extract had no effect on the heart rate, but showed a positive inotropic on the heart and hypotensive effects. These data suggested that hypotensive effect may counterbalance by the inotropic effect of the extract.


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