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SHORT COMMUNICATION
Year : 2011  |  Volume : 7  |  Issue : 26  |  Page : 171-175

Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants


1 Bioorganic and Natural Products Laboratory, Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines
2 Gentaur BVBA, Kampenhout, Belgium
3 Laboratory of Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium

Correspondence Address:
Christine Chichioco-Hernandez
Bioorganic and Natural Products Laboratory, Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101
Philippines
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Source of Support: Office of the Chancellor through the Office of the Vice-Chancellor for Research and Development, University of the Philippines, Diliman, Conflict of Interest: None


DOI: 10.4103/0973-1296.80683

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The genotoxicity and toxicity of ethnomedicinal Philippine plants, which include Cassia fistula, Derris elliptica, Ficus elastica, Gliciridia sepium, Michelia alba, Morus alba, Pogostemon cablin and Ricinus communis, were tested using the Vitotox assay. The plants are used traditionally to treat several disorders like diabetes, weakness, menorrhagia, headache, toothache and rheumatism. The dried leaves were homogenized for overnight soaking in methanol at room temperature. The resulting alcoholic extracts were filtered and concentrated in vacuo and tested for their genotoxicity and cytotoxicity using Vitotox®. Results showed that the medicinal plants that were tested are not genotoxic nor cytotoxic, except for R. communis and P. cablin, which showed toxicity at high doses (low dilutions) in the absence of S9.


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