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ORIGINAL ARTICLE
Year : 2010  |  Volume : 6  |  Issue : 23  |  Page : 234-237

Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots


1 Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
2 Department of Chemistry, Sofia University "St. Kl. Ohridski", 1164 Sofia, Bulgaria

Correspondence Address:
Antoaneta Trendafilova
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia
Bulgaria
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Source of Support: TK-X-1609 provided by the National Science Fund of Bulgaria, Conflict of Interest: None


DOI: 10.4103/0973-1296.66942

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This work deals with ultrasound-assisted extraction (UAE) of alantolactone and isoalantolactone from the roots of Inula helenium L., a well-known medicinal plant. The effects of ethanol concentration, extraction time, temperature and number of extraction steps on the extraction yields of both sesquiterpene lactones were investigated. Gas chromatographic (GC) method was used for simultaneous determination of their contents in the corresponding extracts. A comparison with classical extraction methods [maceration, infusion and micro steam distillation-extraction (MSDE)] showed that the amounts of alantolactone and isoalantolactone achieved by UAE with 70 and 96% EtOH for 30 min at room temperature were higher or almost equal to those obtained by maceration for 24 hours.


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