Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 20  |  Page : 388-393

Antimutagenic potential and phytochemical analysis of selected Philippine plants


1 Institute of Chemistry, University of the Philippines, Diliman, Philippines
2 Natural Sciences Research Institute, University of the Philippines, Diliman, Philippines

Correspondence Address:
Christine L Chichioco-Hernandez
Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City, Philippines 1101
Philippines
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Chemopreventive agents can act to prevent or stop genetic mutation that can lead to cancer. Several promising chemopreventive agents include vitamins, minerals and phytochemicals, all of which are obtained from plants. Natural products derived from plants continue to be a fertile source of cure for cancer. In this study, selected Philippine plants were tested for their ability to inhibit chromosomal damage induced by tetracycline in the in vivo micronucleus test (MT). The methanolic extract of Canarium ovatum Engl., locally recognized as pili, showed the most promising activity by reducing the number of micronucleated polychromatic erythrocytes by 54.41% in the preliminary MT screening. Bioactivity-guided fractionation of the crude methanol extract of C. ovatum leaves have identified the most active portion in the hexane fraction. Further isolation and purification will be done to determine the constituent/s responsible for the observed antimutagenic activity in C. ovatum. Identification and characterization of the bioactive compound/s in this plant could be a starting point in the search for other chemopreventive substances, and for the possible synthesis and development of more efficacious agents.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7645    
    Printed231    
    Emailed3    
    PDF Downloaded108    
    Comments [Add]    

Recommend this journal