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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 20  |  Page : 324-328

Cytotoxic and Antibacterial Constituents from the Roots of Sonchus oleraceus L. Growing in Egypt


Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut 71524, Egypt

Correspondence Address:
Ehab Saad Elkhayat
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut 71524
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.58154

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Phytochemical study of the roots of Sonchus oleraceus L. (Astraceae) Growing in Egypt, afforded loliolide 1 for the first time from the genus Sonchus in addition to 15-O- β -glucopyranosyl-11 β ,13-dihydrourospermal A 2 , ursolic acid 3 , lupeol 4 and β-sitosterol- 3-O-glucopyranoside 5 for the fi rst time from the plant. The biological evaluation of the isolated compounds showed cytotoxic activity of 1 and 2 against PC33 and L5187Y cell lines, in addition to antibacterial activity against S.aureus , B. subtilis , E. Coli and N. gohnorea . The structures of the compounds were elucidated using 1D ( 1 H and 13C), 2D (H-H COSY, H S QC and HMBC) NMR and MS spectroscopic data.


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