Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 19  |  Page : 93-99

Formulation and evaluation of topical polyherbal antiacne gels containing Garcinia mangostana and Aloe vera


Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumarawsamy Layout, Bangalore-560078, India

Correspondence Address:
Gowda Bhaskar
Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumarawsamy Layout, Bangalore-560078
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The objective of the study was to develop a topical poly herbal gel for the treatment of mild acne vulgaris. Aqueous extracts of Garcinia mangostana and Aloe vera were formulated in an aqueous based carbopol-934(1%w/w) gel system. Preformulation studies on solubility, partition co-efficient, MIC, MBC were determined along with compatibility studies using a validated HPLC method. Six formulations of the gel were prepared by varying the proportions of polymers and evaluated for their physicochemical properties like pH, spreadability, viscosity and microbial assay. Based on these tests, formulation F-6 containing 1% carbopol-934 was selected as best formulation and carried over to in-vitro drug diffusion studies wherein it showed Cumulative Drug Release of 81.03% at the end of 8 hours with a flux of 0.0879 mg/cm2/hr.The microbial assay of all the formulations demonstrated better inhibitory activity against Propionibacterium acne and Staphylococcus epidermidis compared to the marketed clindamycin phosphate gel in equivalent amounts of application. Conclusion: It was concluded from the study that aqueous extract of Garcinia mangostana and Aloe vera can be formulated in an aqueous based gel system for topical therapy of mild acne vulgaris.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed10453    
    Printed233    
    Emailed11    
    PDF Downloaded117    
    Comments [Add]    
    Cited by others 4    

Recommend this journal