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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 19  |  Page : 51-54

Antidiabetic activity of aqueous extract of Eucalyptus citriodorahook. in alloxan induced diabetic rats


1 College of Pharmacy, IFTM, Moradabad 244 001, U.P; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835 215, Ranchi, Jharkhand, India
2 Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835 215, Ranchi, Jharkhand, India
3 Department of Pharmaceutics, IT, BHU, Varanasi, India

Correspondence Address:
Arjun Patra
College of Pharmacy, IFTM, Moradabad 244 001, U.P; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra 835 215, Ranchi, Jharkhand
India
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Source of Support: None, Conflict of Interest: None


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The present study was undertaken to study the antidiabetic activity of the aqueous extract of Eucalyptus citriodora Hook. leaf in alloxan-induced diabetic rats. The activity of the extract was studied on glucose loaded and alloxan-induced diabetic rats. In both the tests, the extract has shown significant and considerable antidiabetic effect in a dose dependent manner. On oral administration of the extract at a dose of 500 mg/kg of body weight, the reduction of blood glucose level was 22.9% after 4th hr and on continuous administration the reduction in blood glucose level after 21 days was 49.9 and 56.8% with dose of 250 and 500 mg/kg of body weight respectively. Aqueous extract of leaves of E. citriodora exhibited significant antidiabetic activity which was comparable with the standard drug Glibenclamide.


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