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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 19  |  Page : 46-50

Synergistic effect of Withania somnifera dunal and L-dopa in the inhiition of haloperidol-induced catalepsy in mice


Department of Pharmacology, B. N. College of Pharmacy, Udaipur-313 002 (Rajasthan), India

Correspondence Address:
Chand Rana Avtar
Department of Pharmacology, B. N. College of Pharmacy, Udaipur-313 002 (Rajasthan)
India
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Source of Support: None, Conflict of Interest: None


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The possible synergism between WS and dopamine precursor L-dopa to inhibit haloperidol-induced catalepsy was investigated by using standard bar test in mice. The effect of WS (20-200 mg/kg, oral), L-dopa (20-200 mg/kg, oral) plus carbidopa and combination of subeffective doses of WS (20 or 50 mg/kg, oral) prior to L-dopa (20, 50 or 100 mg/kg, oral) plus carbidopa was assessed in haloperidol (1 mg/kg, i.p.) induced catalepsy. L-dopa and carbidopa combination was always administered in 10:1 ratio. WS (100 or 200 mg/kg, oral) and L-dopa (50, 100 or 200 mg/kg, oral) plus carbidopa treated groups showed a dose dependent reduction in cataleptic scores. Subeffective doses of WS (20 or 50 mg/kg, oral) prior to L-dopa (20, 50 or 100 mg/kg, oral) also potentiated the anticataleptic effect of L-dopa. These results indicate that subeffective doses of WS enhance the anticataleptic actions of L-dopa and the possibility of using WS as adjunctive therapy to reduce the doses and the adverse effects of dopamine precursor in Parkinson's disease.


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