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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 19  |  Page : 42-45

Hypoglycemic activity of the bark of Spondias pinnata Linn. kurz.


Matushree V. B. Manvar College of Pharmacy, Dumiyani, Rajkot district, Gujarat -360 440, India

Correspondence Address:
S Mondal
Matushree V. B. Manvar College of Pharmacy, Dumiyani, Rajkot district, Gujarat -360 440
India
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Source of Support: None, Conflict of Interest: None


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Diabetes, the most prevailing metabolic disorder is attracting present research attention towards it. In the present study, the various extracts of the barks of Spondias pinnata (Family: Rubiaceae) was evaluated for hypoglycemic activity on adult Wistar albino rats at dose levels of 300 mg/kg p.o. each using normoglycaemic, glucose loaded and alloxan induced hyperglycaemic rats. Glibenclamide (2.5 mg/kg) was used as reference standard for activity comparison. Among the tested extracts, the methanol extract was found to produce promising results that is comparable to that of the reference standard glibenclamide. The preliminary phytochemical examination of the methanol extract revealed presence of flavonoids, tannins, saponins and terpenoids. The present work justifies the use of the bark in the folklore treatment in diabetes.


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