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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 19  |  Page : 19-22

Phytochemical and anti-ulcer investigations of the whole plant extract of Neregamia alata wight & Arn. in albino rat model


1 Department of Pharmaceutics, Roa’s College of Pharmacy, Chemudtgunta, Venkatachalam (M), Nellure, Andhra Pradesh - 524 320, India
2 Department of Pharmaceutics, Kakatiya Institute of Pharmaceutical Sciences, Pembarthi (V), Hasanparthy (M), Warangal, Andhra Pradesh - 506 371, India
3 Department of Pharmacognosy, Vagdevi College of Pharmacy, Guruzala, Guntur (D), Andhra Pradesh, India
4 Department of Pharmaceutics, C.M.R. College of pharmacy, Banaswadi, Bangalore, Karnataka-560 043, India
5 Executive, Regulatory Affairs, Strides Arcolab Limited, Bangalore Karnataka 560076, India

Correspondence Address:
M Purushothaman
Department of Pharmaceutics, Roa’s College of Pharmacy, Chemudtgunta, Venkatachalam (M), Nellure, Andhra Pradesh - 524 320
India
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Source of Support: None, Conflict of Interest: None


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The purpose of the present study is to investigate the chemical constituents and anti-ulcer profile of the methanolic extract of Neregamia alata Wight & Arn. (MENA) whole plant in albino rats. The phytochemical examination of methanolic extract of whole plant of Neregamia alata was performed by the standard methods. MENA at the doses of 125, 250 and 500 mg/kg body weight orally was administered to evaluate anti-ulcer activity by using pyloric ligation (PL) and hypothermic-restraint stress (HRS) induced gastric ulcer models in Albino rats. MENA, at doses of 125, 250 and 500 mg/kg were found to be protective (36.47, 45.86 and 75.02% respectively), in PL induced ulcer models and significantly reduced free and total acidity by P Neregamia alata as a potent anti-ulcer agent.


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