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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 17  |  Page : 49-54

Antinociceptive Effects of Newbouldia laevis (P. Beauv.) Stem Bark Extract in a Rat Model


Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana

Correspondence Address:
Eric Woode
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science & Technology, Kumasi
Ghana
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Source of Support: None, Conflict of Interest: None


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Various parts of Newbouldia laevis (fam. Bignoniaceae) are used for pain and several inflammatory conditions in Ghana. This study presents the effect of a hydro-alcoholic extract of N. leavis stem bark in formalin-induced pain, a model of neuropathic pain, in rats. Morphine (1-10 mg kg -1 i.p) and stem bark extract of N. laevis (10-300 mg kg -1 p.o.),dose-dependently decreased both phases of the formalin-induced nociceptive behaviour. Nocifensive response for morphine was four fold higher in the first phase (ED 50; 7.59 0.63 mg kg -1 ) compared to the second (ED 50 ;7.59 2.26) ; however the response for the extract was similar in both phases (ED 50; first phase 28.287.02; ED 50; second phase 25.07 5.83). Diclofenac (10-100 mg kg -1 ) was effective only in the second phase (ED 50 33.24 5.20). The potency of the drugs was in the order; morphine > extract > diclofenac for the first phase and morphine > extract = diclofenac for the second phase. The results from this study show that N. laevis extract has central and peripheral analgesic properties and thus adds credence to its traditional uses.


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