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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 17  |  Page : 28-36

Chemical Composition and Hepato-protective activity of Imperata cylindrica Beauv


1 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
2 Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
3 Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
4 Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan

Correspondence Address:
Ehab S Elkhayat
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524
Egypt
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Source of Support: None, Conflict of Interest: None


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Phytochemical study of the aerial parts of Imperata cylindrica Beauv. (Graminae), growing in Egypt afforded four methoxylated flavonoids 1-4 , β-sitosterol-3-0-β-D-glucopyranosyl-6 ' -tetradecanoate 5 , 3-hydroxy-4-methoxy­benzaldehyde 6 , together with daucosterol, β-sitosterol and α-amyrin 7-9. To the best of our knowledge, this is the first isolation of compounds 1-5 from the genus Imperata. A significant hepato-protective activity had been observed upon co-administration of the methanolic extracts of I. cylindrica with CCl 4 . The structures were determined using spectroscopic data; 1D ( 1 H and 13 C), 2D (HSQC, and HMBC) NMR; MS; UV and IR.


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